Drug alert: common painkiller increases the risk of miscarriage

According to UCLA Health System, it is estimated that up to half of all fertilized eggs die and are lost spontaneously, usually before the woman knows she is pregnant. Among those women who know they are pregnant, the miscarriage rate is about 15-20%. Most miscarriages occur during the first seven weeks of pregnancy. The rate of miscarriage drops after the baby’s heart beat is detected. Many factors such as hormone irregularities or infections can increases the risk of miscarriage; however, a new one has been added to the list: non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs). Examples of non-aspirin NSAIDs are ibuprofen (i.e., Advil, Midol, and Motrin) and naproxen (i.e., Anaprox and Advil). On September 6, Canadian researchers published the results of their study online in the Canadian Medical Association Journal. It reported that the ingestion of non-aspirin NSAIDs in early pregnancy is linked to twice the risk for miscarriage. “The association between the use of …NSAIDs during pregnancy and the risk of spontaneous abortion [miscarriage] remains unclear because of inconsistent research results and the lack of evidence for an effect due to specific types or dosages of non-aspirin NSAIDs,” wrote Hamid Reza Nakhai-Pour, MD, PhD, from the University of Montreal and CHU Ste-Justine in Quebec, Canada, and colleagues. “We aimed to quantify the association between having a spontaneous abortion and types and dosages of non-aspirin NSAIDs in a cohort of pregnant women.”

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A total of 4,705 women who suffered a spontaneous abortion were identified from the Quebec Pregnancy Registry. (The medical term for miscarriage is “spontaneous abortion.) For each patient, the investigators randomly selected 10 control participants from other women in the registry, matching by index date, defined as the date of the spontaneous abortion, and by gestational age. Case patients and control participants were compared in use of non-aspirin NSAIDs, as reflected in filled prescriptions. The investigators analyzed associations between different types and dosages of non-aspirin NSAIDs and spontaneous abortion. Of the 4,705 patients with spontaneous abortion, 352 (7.5%) had NSAID exposure, as did 1,213 (2.6%) of 47,050 control participants. The use of non-aspirin NSAIDs during pregnancy was associated with a 2.43 times greater risk for spontaneous abortion. There was no apparent dose-response effect; thus, even small doses increased the risk. The authors concluded: “Gestational exposure to any type or dosage of non-aspirin NSAIDs may increase the risk of spontaneous abortion.”

Source: http://www.edtreatmentindia.com/

Another smoking negative: earlier menopause

One in five women in Los Angeles smoke, according to the Los Angeles County Department of Public Health. A new study, published September 18 in the journal menopause, adds another reason that smoking impacts a woman’s health: earlier menopause. Study author Dr. Volodymyr Dvornyk, from the University of Hong Kong, noted that women “should be aware of this effect and possible health consequences” of smoking, in addition to its other known risks. He and his research team conducted a meta-analysis, which pooled data from six studies of approximately 6,000 women in the U.S., Poland, Turkey, and Iran. It revealed that women who smoke may enter menopause about a year earlier than nonsmokers. On the average, non-smokers reached the menopause between age 46 and 51, on average, depending on the study population. In all but two of the studies, smokers were younger: between age 43 and 50. The researchers also reviewed five other studies that used a cut-off age of 50 or 51 to stratify women into “early” and “late” menopause groups. Among the more than 43,000 women in that analysis, smokers were 43% more likely than nonsmokers to have early menopause. They wrote, “Our results give further evidence that smoking is significantly associated with earlier [age at menopause] and provide yet another justification for women to avoid this habit.”

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Dr. Dvornyk noted that the “general consensus is that earlier menopause is likely to be associated with the larger number and higher risk of postmenopausal health problems, such as osteoporosis, cardiovascular diseases, diabetes mellitus, obesity, Alzheimer’s disease, and the others.” He added that early menopause is also thought to slightly increase a woman’s risk of death in the years following. Two theories regarding smoking and early menopause are (1) Smoking may alter the way a women’s body produces or removes estrogen; and (2) Certain components of cigarette smoke might kill ova (eggs). Dr. Dvornyk and his colleagues did not have information on how long women had been smoking or how many cigarettes they smoked each day; therefore, they could not determine how either of those factors may have affected age at menopause.

In addition to the foregoing health effects of smoking are cosmetic issues. Smoking increases facial wrinkles, stains your teeth, makes your voice hoarse, and gives you bad breath.

Source: HEALTH AND WELLNESS BLOG INDIA

Prevent diabetes with nutrition and exercise, not pills

Nutrition and exercise can delay diabetes for at least a decade and those lifestyle changes work better than a popular drug.

In the late 1990s, the Diabetes Prevention Program randomly assigned, to one of three groups, roughly 3,200 people who were at risk for diabetes because they were overweight or obese and had fasting blood sugar levels that were elevated (at least 95 mg/dL) but not high enough to warrant a diagnosis of diabetes (126 mg/dL or higher).

Those assigned to the intensive lifestyle group were encouraged to lose at least 7 percent of their body weight and to exercise for at least 2½ hours a week.

The drug group was given the oral diabetes drug metformin (850 milligrams twice a day).

The placebo group was given lookalike but inactive pills.

In 2001, the researchers halted the study one year earlier than planned because the results were so clear: The risk of diabetes was 58 percent lower in the intensive lifestyle group than in the placebo group.

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Metformin cut the risk by 31 percent versus the placebo. In a follow-up study, the researchers invited the people from all three of the original groups to attend coaching sessions on intensive lifestyle changes every three months.

During the next six years, the people from the original intensive lifestyle group maintained their lower risk of diabetes, while the risk of people from the original drug and placebo groups declined.

But since the people in the original lifestyle group had a head start, their 10-year risk of diabetes was 34 percent lower than the risk of those in the original placebo group. The metformin group’s risk was 18 percent lower than the original placebo group’s.

Type 2 diabetes is associated with obesity, especially abdominal obesity. Type 2 diabetics usually produce enough insulin but their cells are insulin resistant. This can result in hyperglycemia (high blood sugar). If left uncorrected, it leads to kidney, heart, eye and nerve damage.

Source: HEALTH AND WELLNESS BLOG INDIA

You can prevent diabetes even if you are pre-diabetic. Start eating better and exercising regularly. Start today.

5 secrets about raspberry ketones and weight loss

Raspberry ketones seems to be a current superstar in the weight loss arena. Its important to remember that for you to achieve permanent weight loss, it takes many changes and adjustments on your part. When you rely on a single “weight loss product,” diet or fitness gadget to build a lean and healthy body, you are setting yourself up for failure.

For long-term weight loss success to happen, you will need to commit to a lifestyle of health and fitness. There are no shortcuts. Quick weight loss gimmicks will lead you to more weight regain and excess body fat.Yes, permanent weight loss success will always primarily be about what, when and how much you eat and whether you are consistently exercising and be active. Let those facts sink into your subconscious.

Here are 5 secrets about raspberry ketones provided by Kevin DiDonato, MS, CSCS, CES:

1. Raspberry ketones has been around since 1965, but until recently, was not researched extensively. The nutrient has been made famous by Dr. Oz.

Raspberry ketones, otherwise known as rheosmin, has been shown in research to increase fat metabolism in your fat cells. Research suggests that aromatic components in red raspberries work by increasing enzyme activity, increasing oxygen consumption, and increasing heat production in some fat cells in your body. Put together, this may lead to lower levels of fatty acids being stored in your fat cells – resulting in more weight loss.

2. Raspberry ketones has also been linked to an increase in the expression of adiponectin levels in your blood, which could stimulate increased energy expenditure. According to one study published in Planta Medica, exposure of raspberry ketones in fat cells may be linked to increased fat oxidation and adiponectin levels.

Adiponectin, which is a protein secreted exclusively from your fat cells, has been linked to increased fatty-acid oxidation and fatty-acid breakdown. It has been shown to be decreased in overweight or obese individuals, but losing weight has been shown to dramatically increase your levels.

3. Adiponectin has been shown to impair your immature fats cells (pre-adipocytes) from turning into mature, full-fledged fat cells. Plus, it may increase energy expenditure. Raspberry ketones, according to some clinical studies, has been shown to raise adiponectin levels, which could partly explain the powerful effects of raspberry ketones.

The author of this study aimed to evaluate the effects of raspberry ketones on the expression and secretion of adiponectin, lipolysis, and fatty-acid oxidation in white fat cells.

4. White fat cells (different than brown, beige, or visceral fat) are cells that store extra fatty acids circulating in your blood for later use. They are also responsible for hormone and cytokine secretion, which makes fat cells an endocrine organ in your body.

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The researchers administered raspberry ketones to white adipose fat cells. They discovered that raspberry ketones increased lipolysis significantly in white fat cells; plus, it increased the expression and secretion of adiponectin in those same cells. Also, he noted that raspberry ketones was able to increase fat oxidation and suppress fat accumulation in those very same fat cells.

From their work, they concluded that raspberry ketones showed promise as an herbal medicine due to their biological activities in promoting greater lipid metabolism in white fat cells.

5. Raspberry ketones, the aromatic polyphenol found in red raspberries, has received tremendous media exposure as of late due to their ability to improve weight loss results, and rightly so. Raspberry ketones may increase fatty-acid oxidation, increase lipolysis, and increase the expression and secretion of adiponectin (powerful adipokine released by your fat cells).

In fact, the results of this study showed that raspberry ketones, when administered to white fat cells, could be responsible for the increase in adiponectin levels, fat burning, and prevention of fat being stored in the fat cells.

Raspberry ketones, along with a balanced diet and sound exercise program, may increase fat burning and reduce overall fat accumulation in your cells.

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Weight loss and Vitamin D

Los Angeles is in the Sun Belt; thus, most women in the city can increase Vitamin D levels by simply spending time in the sun. It is common knowledge that adequate Vitamin D is necessary for health; however, a new study has found that circulating Vitamin D concentrations in postmenopausal women are directly associated with weight loss, whether achieved through decreasing calories or increasing physical activity. The study was conducted by researchers at the Fred Hutchinson Cancer Research Center in Seattle, Washington. The authors noted that low concentrations of circulating Vitamin D are common on obese postmenopausal women and may represent a potential mechanism explaining the elevated risk of certain cancers and cardiovascular disease observed in obese or overweight individuals. The objective of the study was to investigate the effects of 12 months of weight loss through caloric restriction, exercise intervention, or both on serum Vitamin D levels.

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The study group was comprised of 438 overweight and obese postmenopausal women: 118 were assigned to dietary modification; 117 were assigned to an exercise intervention; 117 were assigned to diet plus exercise; and 87 were assigned to a control group. Women receiving the dietary intervention experienced a 10% weight loss goal using a group-based reduced-calorie program. The women assigned to the exercise intervention underwent 45 minutes of moderate to vigorous intensity aerobic activity daily for five days each week. The investigators measured serum Vitamin D levels at baseline and at 12 months. Women who lost the most weight had the largest increase in Vitamin D levels. The authors concluded that a greater degree of weight loss, achieved through either a reduced-calorie diet or increased exercise, is associated with increased circulating Vitamin D concentrations. They noted that although greater adiposity is associated with lower concentrations of circulating vitamin D, their findings suggest that lifestyle-based weight loss of 5% to 10% body weight is associated with a modest increase in serum Vitamin D; however, baseline vitamin D status had little effect on the achievement of weight loss in a sample of overweight and obese postmenopausal women. They recommended that further research should be conducted to better understand the role of vitamin D in pathways influencing energy balance and that this research may lead to a clearer understanding of optimal vitamin D concentrations for promoting health.

Sexy fitness Girl in Health Club

Source: HEALTH AND WELLNESS BLOG INDIA

Vitamin E may increase risk of prostate cancer

Many Angelenos take one or more—sometimes a dozen or more—vitamins daily; however, that may not be a good thing. Falling on the heels of a study published October 10, which suggested an increased risk of death for older women taking vitamin and mineral supplements, is a new study on men taking vitamin and mineral supplements. The study, which was published in the October 11 issue of the Journal of the American Medical Association, reported that men taking Vitamin E and selenium had a slightly higher risk of developing prostate cancer. These two new studies add to the growing body of evidence that taking extra doses of vitamins can do more harm than good. “You go back 15 or 20 years, and there were thoughts that antioxidants of all sorts might be useful, said Dr. Eric Klein, a Cleveland Clinic physician and national study coordinator for the prostate cancer and vitamin E study. He added, “There really is not any compelling evidence that taking these dietary supplements above and beyond a normal dietary intake is helpful in any way, and this is evidence that it could be harmful.

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The Selenium and Vitamin E Cancer Prevention Trial, which was dubbed the Select trial, evaluated whether selenium and Vitamin E, either alone or in combination, could lower a man’s risk for prostate cancer. The trial was halted early in 2008 after a review of the data showed no benefit. Furthermore, it found a slight risk of prostate cancer and diabetes that wasn’t statistically significant. The latest data, based on longer-term follow-up of the men in the trial, reported that users of Vitamin E had a 17% higher—and statistically significant—risk of prostate cancer compared with men who did not take the vitamin, a level that was statistically significant. There was no increased risk of diabetes.

The dosage evaluated in the Select trial was 200 micrograms of selenium and 400 international units of vitamin E. By comparison, most multivitamins contain about 50 micrograms of selenium and 30 to 200 international units of vitamin E. The authors concluded: “Based on existing evidence, we see little justification for the general and widespread use of dietary supplements. Everyone requires vitamins, which are essential nutrients that the body cannot manufacture; however, in the past few years, several high-quality studies have failed to show that high doses of vitamins, at least in pill form, help prevent chronic disease or prolong life.

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Neanderthal diet featured meat and veg Paleo diet optimized for weight loss

Chomp, chomp. A new study has revealed that Neanderthals consumed meat and plants, supporting previous theories that their diets featured protein, reported Businessweek on Wednesday. And although there are similarities, the modern Paleo diet has been modified to boost weight loss and health, say experts.

After finding evidence of metabolized plant products in fossilized feces, researchers have more knowledge about precisely what Neanderthals ate, said Ainara Sistiaga, the study’s lead author. And although meat appeared to provide them with most of their fuel, the plant poop proves that veggies “were ingested as part of the diet.”

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However, when it comes to percentages, the Neanderthals consumed more meat than greens. That conclusion stems from the discovery that the samples contained high concentrations of broken-down cholesterol similar to modern humans, said Sistiaga.

The poop study provides a new slant, indicating that Neanderthals were omnivorous rather than carnivorous, reported Slate magazine on Wednesday. It’s also one of the most in-depth reports thus far, since other studies were based more on speculation.

Scientists also are intrigued by what happened after they discovered fire, estimated to be two million years ago. Researchers theorize that event resulted in a boost in meat intake. “They probably weren’t prepared for such a high meat intake,” speculates Sistiaga.

So how does this study compare with what modern Paleo dieters eat? They both are low carb diets, and both eliminate dairy and grain. However, Paleo gurus emphasize that caveman dieters can customize the plan to enhance their health.

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In an exclusive interview, Robb Wolf, author of “The Paleo Solution: The Original Human Diet,” told me that many people don’t understand the caveman concept approach, which emphasizes quality over quantity. The “calories in, calories out” concept has failed to reverse the rising rates of obesity and its accompanying diseases such as cholesterol.

Insisting that humans need grains and dairy implies that “all food is equal,” says Robb. “The ‘everything in moderation crowd’ (which refers to mainstream medicine and dietetics) has had the last 50 years to preach this message and it has been a complete failure.”

And the Paleo diet today is not limited to meat and veggies. Robb’s research shows that the healthiest approach for dieters is to create a diet “built around fruits, veggies, lean meats, nuts and seeds.”

After numerous studies, Robb feels it is clear that a Paleo diet not only “provides all the nutrients for health, but that the Paleo diet is, calorie for calorie, the most nutritious way one can eat. This position that removing grains and dairy is inherently unhealthy is not based on science.”

Expanding on the omnivorous low carb diet approach, Robb notes that the use of resistant starch in modern Paleo diets highlights “the bigger topic of the human gut biome.” In contrast, consuming refined carbohydrates “appear to feed bacteria in the small intestine leading to a condition aptly named ‘small intestinal bacterial overgrowth.’ This bacterial overgrowth in the small intestine is now being linked to a remarkable number of health issues, from cardiovascular disease to autoimmunity.”

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The recognition of the role of fiber has grown, and “it has only been recently that we have understood the mechanism to be that of feeding our beneficial gut flora. A Paleo diet built around fruits, veggies, roots, shoots, tubers nuts and seeds provides an enormous variety of fermentable carbohydrate to keep our gut bacteria healthy,” Robb added.

Taking the omnivorous concept one step further, Paul and Shou-Ching Jaminet have created a modified Paleo diet that includes fish, meat, vegetables, fruit and what they call “safe starches.” The latter includes rice and potatoes, which they emphasize as key to health and weight loss. It’s all detailed in their book “Perfect Health Diet: Regain Health and Lose Weight by Eating the Way You Were Meant to Eat.”

As Robb notes, a significant body of science supports the theory that by avoiding foods toxic to humans, dieters can both shed pounds and avoid disease. The “Perfect Health Diet” avoids grains, legumes, refined sugars and processed oils. Another advocate of resistant starch is blogger Richard Nikoley. Author of “Free The Animal: Lose Weight & Fat With The Paleo Diet,” he emphasizes that enhancing the traditional Paleo diet in this way can provide benefits ranging from improved sleep to a boost in weight loss.

Weight loss and Vitamin D

Los Angeles is in the Sun Belt; thus, most women in the city can increase Vitamin D levels by simply spending time in the sun. It is common knowledge that adequate Vitamin D is necessary for health; however, a new study has found that circulating Vitamin D concentrations in postmenopausal women are directly associated with weight loss, whether achieved through decreasing calories or increasing physical activity. The study was conducted by researchers at the Fred Hutchinson Cancer Research Center in Seattle, Washington. The authors noted that low concentrations of circulating Vitamin D are common on obese postmenopausal women and may represent a potential mechanism explaining the elevated risk of certain cancers and cardiovascular disease observed in obese or overweight individuals. The objective of the study was to investigate the effects of 12 months of weight loss through caloric restriction, exercise intervention, or both on serum Vitamin D levels.

Health Blog URL: http://blog.edtreatmentindia.com/

The study group was comprised of 438 overweight and obese postmenopausal women: 118 were assigned to dietary modification; 117 were assigned to an exercise intervention; 117 were assigned to diet plus exercise; and 87 were assigned to a control group. Women receiving the dietary intervention experienced a 10% weight loss goal using a group-based reduced-calorie program. The women assigned to the exercise intervention underwent 45 minutes of moderate to vigorous intensity aerobic activity daily for five days each week. The investigators measured serum Vitamin D levels at baseline and at 12 months. Women who lost the most weight had the largest increase in Vitamin D levels. The authors concluded that a greater degree of weight loss, achieved through either a reduced-calorie diet or increased exercise, is associated with increased circulating Vitamin D concentrations. They noted that although greater adiposity is associated with lower concentrations of circulating vitamin D, their findings suggest that lifestyle-based weight loss of 5% to 10% body weight is associated with a modest increase in serum Vitamin D; however, baseline vitamin D status had little effect on the achievement of weight loss in a sample of overweight and obese postmenopausal women. They recommended that further research should be conducted to better understand the role of vitamin D in pathways influencing energy balance and that this research may lead to a clearer understanding of optimal vitamin D concentrations for promoting health.

New study on smoking cessation during pregnancy

One out of five women in Los Angeles currently smoke; some of these women are pregnant or attempting pregnancy. Because smoking is harmful to both the mother and her developing fetus, most pregnant smokers make an effort to quit. A new study has reported that counseling alone is inadequate for helping most pregnant women quit smoking. The study, published online August 22 in the British Journal of Obstetrics and Gynaecology, concluded that more research on the use of nicotine replacement and other therapies during pregnancy may be needed. The study reviewed eight clinical trials comprised of a total of almost 3,300 pregnant women. The investigators evaluated whether counseling helped pregnant women quit smoking after six months.

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Four of eight trials showed no difference between groups of pregnant women who got smoking-cessation counseling and those who did not; the other four studies reported just a slightly lower quit rate in women who did not receive the counseling. For example, in the study with the highest success rate, only 24% of women who received counseling were able to quit, compared to 21% who did not receive counseling. Thus, three out of four pregnant women in that study continued to smoke whether they had counseling or not, noted lead author Dr. Kristian Filion from the University of Minnesota in Minneapolis. He explained, “We were a little surprised by the small number of women that remained abstinent and by the small effect of counseling.” He does not recommend abandoning counseling as an intervention; however, he does see a need to study more effective approaches. “Evidence regarding the safety and effectiveness of nicotine replacement therapies in pregnant women is limited,” he said. “More research in this area is needed so that we can better understand the risk-benefit ratio of nicotine replacement therapies in pregnant women.” Using counseling, nicotine replacement and other therapies that might help in a quit attempt before getting pregnant is a woman’s best bet, said Dr. Filion. U.S. Public Health Service guidelines recommend nicotine replacement therapies and drugs such as Wellbutrin (bupropion) and Chantix (varenicline) to help people stop smoking; however, these medications also have a negative effect on the fetus. For example, nicotine constricts arterial blood vessels; thus, the fetus receives less oxygen when nicotine is in the blood stream. However, nicotine alone avoids exposing the fetus to the numerous toxic substances contained in tobacco.

Take Home Message:

It is best to stop smoking without the aid of any substances that can be harmful to the fetus; however, it is better to apply a nicotine patch than light up a cigarette.

Source: http://www.edtreatmentindia.com

Early menopause increases risk of coronary heart disease and stroke

According to the LA County Department of Public Health, coronary heart disease is the leading cause of death for women in the county and stroke is the second leading cause of death for women in the county. A new study has reported that an early menopause increases the risk of both conditions. Researchers affiliated with the University of Alabama, Birmingham published their findings in the October issue of the journal Menopause.

The researchers noted that the identification of women at risk of cardiovascular disease is of major public health importance. They explained that some studies have reported an association with cardiovascular disease events in some predominantly white populations; however, others did not find an association. The objective of the study was to determine if self-reported early menopause (menopause at an before age 46) identifies women as at risk for future coronary heart disease or stroke.

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The researched reviewed data from the Multi-Ethnic Study of Atherosclerosis, which is a longitudinal, ethnically diverse study of US men and women aged 45 to 84 years enrolled in 2000-2002 and followed up until 2008. The investigators evaluated the association between a personal history of early menopause (either natural menopause or surgical removal of ovaries before the age of 46). Future coronary heart disease and stroke was assessed in 2,509 women (age: 45-84; 987 white; 331 Chinese; 641 black; and 550 Hispanic) from the Multi-ethnic Study Atherosclerosis who were free of cardiovascular disease at baseline.

The authors found that of 2,509 women, 693 (28%) reported either surgical or natural early menopause. In survival curves, women with early menopause had poorer coronary heart disease and stroke-free survival. In models adjusted for age, race/ethnicity, Multi-ethnic Study Atherosclerosis site, and traditional cardiovascular disease risk factors, this risk for coronary heart disease and stroke was a 2.08-fold increased risk for coronary heart disease and 2.19-fold greater risk for stroke.

The authors concluded that early menopause was positively associated with coronary heart disease and stroke in a multiethnic cohort, independent of traditional cardiovascular disease risk factors.”

Take home message:

If you experience an early menopause, you should consult with a gynecologist or endocrinologist and mention this study. Hormone replacement therapy (HRT) may be beneficial under these circumstances. Poor lifestyle choices such as smoking have been reported to increase the risk of an early menopause. Smoking also increases the risk of cardiovascular disease.

Source: http://www.edtreatmentindia.com

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